Understanding the functional mechanisms underlying genetic signals associated with complex traits and common diseases, such as cancer, diabetes and Alzheimer's disease, is a formidable challenge. Many genetic signals discovered through genome‐wide association studies map to non‐protein coding sequences, where their molecular consequences are difficult to evaluate. This article summarizes concepts for the systematic interpretation of non‐coding genetic signals using genome annotation data sets in different cellular systems. We outline strategies for the global analysis of multiple association intervals and the in‐depth (...) molecular investigation of individual intervals. We highlight experimental techniques to validate candidate (potential causal) regulatory variants, with a focus on novel genome‐editing techniques including CRISPR/Cas9. These approaches are also applicable to low‐frequency and rare variants, which have become increasingly important in genomic studies of complex traits and diseases. There is a pressing need to translate genetic signals into biological mechanisms, leading to prognostic, diagnostic and therapeutic advances. (shrink)

Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An (...) improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine. Epigenetic and transcriptional variability mediate phenotypic plasticity, enabling adaptation to changing environments. In this review, we describe the sources of inter- and intra-individual variability and discuss epigenetic regulators of gene expression variability, including DNA methylation and chromatin structure. Understanding these molecular mechanisms will improve therapeutic approaches and personalized medicine. (shrink)

After the moral framework of sustainable development, the focus on climate change appears to take a lead in the practice and theory of environmental education. Inherent in this perspective is an apocalyptic message: if we do not rapidly change our use of energy resources, we will severely harm the life conditions of our children and grandchildren. In this article we argue that environmental educators should liberate us from this highly instrumental dictate by taking their cue from our daily care for (...) our environment as revealed in child?s play in nature. Inherent in the interaction of the Homo ludens with nature is a spiral time experience. This time condition elicits a particular responsibility: rather than calculating which means are necessary to prevent future disasters, we should respond with care to the concentric circles of an open and indefinite future. Therefore, environmental education should not aim to prevent future disasters, but foster anticipating care for nature. (shrink)

Depression is vastly heterogeneous in its symptoms, neuroimaging data, and treatment responses. As such, describing how it develops at the network level has been notoriously difficult. In an attempt to overcome this issue, a theoretical “negative prediction mechanism” is proposed. Here, eight key brain regions are connected in a transient, state-dependent, core network of pathological communication that could facilitate the development of depressive cognition. In the context of predictive processing, it is suggested that this mechanism is activated as a response (...) to negative/adverse stimuli in the external and/or internal environment that exceed a vulnerable individual’s capacity for cognitive appraisal. Specifically, repeated activation across this network is proposed to update an individual’s brain so that it increasingly predicts and reinforces negative experiences over time—pushing an individual at-risk for or suffering from depression deeper into mental illness. Within this, the negative prediction mechanism is poised to explain various aspects of prognostic outcome, describing how depression might ebb and flow over multiple timescales in a dynamically changing, complex environment. (shrink)

English summary: It seems that reason is less a universal principle than something inherently bound to the contexts in which it appears. These contributions to a conference held on the occasion of Christoph Schwobel's 60th birthday explore the character of reason's manifold contexts: the grounding of reason in the inner word of God 's Trinitarian life as well as the disclosure of reason and and its limits in human conversation. German description: Vernunft scheint in der Gegenwart weniger ein allgemeines Prinzip (...) als eine in Kontexte eingebundene Grosse zu sein. Die Beitrage einer Tagung anlasslich von Christoph Schwobels 60. Geburtstag, gehen der Frage nach dem Charakter dieser Kontextbindung nach: der Begrundung der Vernunft im trinitarischen Gesprach wie der Erschliessung und Problematisierung der Vernunft im menschlichen Gesprach. Mit Beitragen von V. Brummer, G. van den Brink, C. Drobe, H. J. Eckstein, D.-M. Grube, J. Halfwassen, S. Heine, F. Hermanni, E. Herms, W. Harle, W. Homolka, W. Jeanrond, R. W. Jenson, D. Kelsey, A. F. Koch, A. Kupsch, V. Leppin, P.-C. Lai, P. Lo, A. Min, J. Moltmann, M. Muhling, P. Peterson, M. Sarot, F. Schweitzer, A. Torrance, J. Webster, M. Welker, M. Wendte, M. Wisse, H. Wisskirchen und L. Zak. (shrink)

Do adherents of different religious traditions communicate and, if so, how? What enables them to do so? What is interreligious “communication”? These issues are ad dressed with reference to Wilfred Cantwell Smith's hermeneutical rule, and to inter alia Paul Knitter, Martin Heidegger, Hans-Georg Gadamer, David Tracy, and John Dunne. Four responses to the question as to what permits interreligious communication are criticised. According to a fifth response, on which the author elaborates, interreligious communication is not – as the objectivist (...) claims – possible because members of different religious traditions speak the very same language, or – as the relativist claims – impossible because they speak radically different languages. Adherents of different religions communicate, if at all, by means of an analogical language. This language is the product of persistent efforts to understand the religion/faith of the other as he or she understands it. Paradoxically, the language that permits inter religious communication is thus the product of such communication. Without thereby reverting to objectivism or an essentialist view of religion, the author identifies five “less unstable” similarities between religions. These and other “less un stable” similarities might assist believers in their efforts to under stand the religious other. (shrink)

“Neo-inclusivism” is explained and assessed as an approach to the problem of the conflicting claims to truth of different religions, with reference to inter alia John B. Cobb (Jr.), Gavin D'Costa and Paul Ingram. For the neo-inclusivist the truth of a religious tradition depends on its inclusivistic capacity, i.e. its capacity to assimilate other traditions. For ex ample, by being enriched and transformed through “radical openness” to other traditions, while remaining “committed” to her own tradition – so the neo-inclusivist (...) claims – the theology of the Christian can become “truly global”. Neo-inclusivism seemingly transcends the absolutist habits of inclusivists, i.e. to assess the religious other in view of criteria (the inclusivist's own religious tradition) with which the other does not identify himself or herself. However, the neo-inclusivist plays down the possible limits of inter religious openness and is overly optimistic about the possibility of a “truly global” theology. Moreover, whether the neo-inclusivist's “committed openness” significantly differs from the approach of those who arbitrarily use the definitive norms of their own religious tradition to assess other traditions, is at least debatable. Whatever the case may be, insofar as tolerance cannot tolerate intolerance, the neo-inclusivist is necessarily intolerant, and, in this sense, “absolutist”, towards those who make their own beliefs normative for all and shun themselves from the assessments and new insights of others. S. Afr. J. Philos. Vol.23(1) 2004: 82-107. (shrink)

The Spirit (πνεῦμα) and peace (εἰρήνη) with God as opposed to the Flesh (σάρξ) and hostility (ἔχθρα) with God in Romans 8:6–8. A surprising number of exegetes do not address the question to what exactly εἰρήνη refers in Romans 8:6. The rest seem to be divided between interpreting it as an unspecified (eschatological) state of peace (šalôm), peace with one’s fellow humans, or peace with God. Based on the textual context, this article argues that the latter interpretative option is best. (...) In terms of metaphor, the relevant target domain here is that of the relationship with God, while the source domain reflected probably is that of diplomatic relations. In addition, peace (with God) here must be understood in relation to the rule of the Spirit, the decisive influence upon those who live κατὰ πνεῦμα (Rom 8:4–5). Antithetically, personified flesh rules over those who are ἐν σαρκί (Rom 8:8). This leads to a disposition of enmity toward God as well as the inability to submit to his law. For Paul being ruled by the Spirit, as a consequence of being reconciled with God through Christ (Rom 5:1, 10; 8:3–4), is a crucial aspect of being at peace with God. (shrink)

Die Kontroversen um Imre Lakatos' "Methodologie wissenschaftlicher Forschungsprogramme" haben zu der Frage geführt, ob auf Basis der von Lakatos entwickelten Standards für die Bewertung von konkurrierenden Theorien und Forschungsprogrammen auch heuristische Empfehlungen begründet werden können, die die von Wissenschaftlern auszuführenden Handlungen im Interesse der Maximierung von Erkenntnisfortschritt normieren. Eine solche Frage steht im Zusammenhang mit einem zentralen Anliegen der Popperschen Wissenschaftstheorie: "Wir wollen die Regeln, oder, wenn man will, die Normen aufstellen, nach denen sich der Forscher richtet, wenn er Wissenschaft (...) treibt, wie wir es uns denken". Ob die Methodologie wissenschaftlicher Forschungsprogramme, die Lakatos als Weiterentwicklung des kritisch-rationalistischen Falsifikationismus verstanden wissen will, diesen Ansprüchen genügt, wurde zuerst von Paul K. Feyerabend und Thomas S. Kuhn bezweifelt. Im folgenden werden zunächst deren Kritiken, die Antworten von Lakatos sowie Analysen von J. J. C. Smart, Wolfgang Stegmüller und Philip Quinn diskutiert. Anschließend wird ein neuer Versuch Alan Musgraves kritisch überprüft, unter Rückgriff auf die Bewertungskriterien der Methodologie wissenschaftlicher Forschungsprogramme heuristische Empfehlungen zu begründen. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:American Journal of Philology 123.1 (2002) 119-122 [Access article in PDF] Mary Depew and Dirk Obbink, eds. Matrices of Genre: Authors, Canons, and Society. Center for Hellenic Studies Colloquia 4. Cambridge, Mass.: Harvard University Press, 2000. vi + 346 pp. Cloth, $50. The present collection of essays, which originated as a colloquium at the Center for Hellenic Studies, starts, in the words of editor and organizer Dirk (...) Obbink, from the premise that "genre is a conceptual orienting device that suggests to the hearer the sort of receptorial conditions in which a fictive discourse might have been delivered." Obbink goes on to note that, as the discussion at the colloquium developed, "a more text-based conception of authorial performance" began to emerge (6). This evolution in turn parallels the movement in the volume from an initial discussion of archaic and classical Greek genres to those of Hellenistic poetry and its Roman imitators. One can only applaud this attempt to provide a more sophisticated framework for the reading and reception of ancient literature. As befits the stature of the sponsoring institution and of the many distinguished participants, all the contributions are of an unquestionable competence. In the end, however, it is unclear that we have achieved a more complex, refined, or problematized concept of genre than that with which we began. Indeed, with a few exceptions, most of the modern debates about the concept of genre are either ignored or cited in passing rather than directly engaged. Nonetheless, there are a number of interesting and important individual papers in this volume and only a few that disappoint.Among the most praiseworthy is Eric Csapo's "From Aristophanes to Menander? Genre Transformation in Greek Comedy." Csapo takes dead aim at the traditional narrative of the evolution from a politically engaged Old Comedy of ribald invective to an apolitical plot-centered New Comedy typified by Menander and his Roman epigones. Csapo's argument is that this narrative was manufactured, not through the accidents of preservation, but through a deliberate selection and canonization of texts by early Peripatetic critics and scholars. When we characterize Old Comedy as being typified by Aristophanes' carnivalesque assaults on the Athenian political establishment and then point to his plays as proof, we are not only engaging in circular reasoning, we are also treading a path that has been deliberately and tendentiously drawn for us. Thus, while the traditional narrative depicts a linear evolution from iambic to Old Comedy to New Comedy, which is portrayed as a movement from the personal and the topical to the universal and the apolitical, Aristotle himself, as Csapo notes (117), admits that Crates, Aristophanes' predecessor, abandoned the iambic and began to compose generalizing plots (Po. 1449b7-8). In short, plots of the kind deemed [End Page 119] typical of New Comedy are to be found at the very beginning of the comic form. By the same token, we have evidence of political comedy surviving well past Aristophanes' supposed invention of the Middle Comic style in the Plutus. Indeed, the last example of an Athenian comedy of political invective is Demetrius' Areopagite, dating from circa 294 B.C.E.Csapo's argument, of course, is not a simpleminded refusal to acknowledge change but rather an attempt to rethink the historical evolution of the comic genre outside the bounds of a narrow, teleological narrative. Genres are always complex negotiations between competing conceptions of the same form by different producers and consumers. At various times, for various intrinsic and extrinsic reasons, different versions of the same form will be ascendant or fading into eclipse. But it is never a question of an essence that either unfolds its fullness over time or declines from a single ideal instantiation.Less revolutionary but equally persuasive is Joseph W. Day's "Epigram and Reader: Generic Force as (Re-)Activation of Ritual." Day examines the relation between dedicatory epigrams on cult statues and their ritual contexts by arguing that the dedicatory genre is essentially performative rather than constative. These epigrams do their social work by activating a performative context in the mind of the reader... (shrink)

Wide-ranging essays making up the first major study of Nietzsche and the classical tradition in a quarter of a century. This volume collects a wide-ranging set of essays examining Friedrich Nietzsche's engagement with antiquity in all its aspects. It investigates Nietzsche's reaction and response to the concept of "classicism," with particular reference to his work on Greek culture as a philologist in Basel and later as a philosopher of modernity, and to his reception of German classicism in all his texts. (...) The book should be of interest to students of ancient history and classics, philosophy, comparative literature, and Germanistik. Taken together, these papers suggest that classicism is both a more significant, and a more contested, concept for Nietzsche than is often realized, and it demonstratesthe need for a return to a close attention to the intellectual-historical context in terms of which Nietzsche saw himself operating. An awareness of the rich variety of academic backgrounds, methodologies, and techniques of reading evinced in these chapters is perhaps the only way for the contemporary scholar to come to grips with what classicism meant for Nietzsche, and hence what Nietzsche means for us today. The book is divided into five sections -- The Classical Greeks; Pre-Socratics and Pythagoreans, Cynics and Stoics; Nietzsche and the Platonic Tradition; Contestations; and German Classicism -- and constitutes the first major study of Nietzsche and the classical tradition in a quarter of a century. Contributors: Jessica N. Berry, Benjamin Biebuyck, Danny Praet and Isabelle Vanden Poel, Paul Bishop, R. Bracht Branham, Thomas Brobjer, David Campbell, Alan Cardew, Roy Elveton, Christian Emden, Simon Gillham, John Hamilton, Mark Hammond, Albert Henrichs, Dirk t.D. Held, David F. Horkott, Dylan Jaggard, Fiona Jenkins, Anthony K. Jensen, Laurence Lampert, Nicholas Martin, Thomas A. Meyer, Burkhard Meyer-Sickendiek, John S. Moore, Neville Morley, David N. McNeill, James I. Porter, Martin A. Ruehl, Herman Siemens, Barry Stocker, Friedrich Ulfers and Mark Daniel Cohen, and Peter Yates. Paul Bishop is William Jacks Chair of Modern Languages at the University of Glasgow. (shrink)

Ce deuxième tome des Hommes de la fraternité s'achève avec le règne de Constantin et le concile de Nicée (325). Les quelques deux cent cinquante évêques qui participent à ce concile dit " œcuménique " représentent bien mal, par leur provenance, ce qu'on appelait alors l'oïkouméné (l'ensemble des terres habitées). Mais le concile est présidé par l'empereur, et une ère nouvelle commence pour les chrétiens au sein de l'Empire. Ils sont si bien traités par le prince, ces évêques conciliaires, qu'ils (...) " se demandent s'ils ne sont pas déjà dans le Royaume de Dieu ". Il semble loin le temps de l'épître à Diognète (vers 195) qui parlait des chrétiens en ces termes : " toute terre étrangère leur est une patrie, toute patrie une terre étrangère. " avec Constantin s'inaugure ce qu'on appellera plus tard l'alliance du trône et de l'autel. Ce deuxième tome est celui d'un tournant décisif pour la suite de l'histoire. Mais l'historien qu'est Michel Clévenot se garde bien d'illustrer une thèse, fût-elle éclairante. Il donne au contraire à voir et à entendre la diversité des situations aux quatre coins de l'Empire et au sein des classes sociales si peu homogènes : le lecteur fait connaissance avec le " directeur de conscience " de la bourgeoisie d'Alexandrie, mais il visite aussi les petits agriculteurs d'Italie, d'Afrique du Nord ou des bords du Nil. Les querelles commerciales, les tensions économiques, les controverses théologiques, les affrontements politiques et guerriers, rien de tout cela n'est négligeable pour celui qui entend " l'appel de Jésus à ne pas déserter l'Histoire ". (shrink)

Spinoza and Moral Freedom guides the reader through Spinoza's principal ideas and powerful lines of reasoning, clearing up obscurities along the way, while acknowledging the genuine difficulties and gaps.

This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1972.

Activation of resting T lymphocytes through the T cell antigen receptor complex is initiated by critical phosphorylation and dephosphorylation events that regulate the function and interaction of a number of signaling molecules. Key elements in these reactions are members of the Src, Syk and Csk families of protein tyrosine kinases (PTKs) and the phosphotyrosine phosphatases (PTPases) that regulate and/or counteract them, such as CD45. The PTKs can autophosphorylate and phosphorylate each other at multiple sites and, as the result of these (...) interactions, they are induced to phosphorylate other cellular proteins. These phosphorylation events lead to modulation of enzymatic activities and/or serve as binding sites for other signaling molecules having phosphotyrosine‐binding Src homology 2 (SH2) domains. As a result, these proteins translocate to the receptor complexes and are juxtaposed to the kinases that phosphorylate them. Some of the SH2‐domain‐containing polypeptides lack enzymatic activities and, instead, serve as adapter molecules that couple the signal to downstream effectors, such as regulators of the Ras proteins, and further into serine/threonine‐specific protein kinase cascades. Through largely unknown steps these reactions lead to the transcription of previously silent genes, activation of lymphocyte effector functions, progression through the cell cycle and cell proliferation. (shrink)

Moral psychology studies the features of cognition, judgement, perception and emotion that make human beings capable of moral action. Perspectives from feminist and race theory immensely enrich moral psychology. Writers who take these perspectives ask questions about mind, feeling, and action in contexts of social difference and unequal power and opportunity. These essays by a distinguished international cast of philosophers explore moral psychology as it connects to social life, scientific studies, and literature.

Paul Horwich presents a bold new interpretation of Wittgenstein's later work. He argues that it is Wittgenstein's radically anti-theoretical metaphilosophy - and not his identification of the meaning of a word with its use - that underpins his discussions of specific issues concerning language, the mind, mathematics, knowledge, art, and religion.

In _ Plato's Camera_, eminent philosopher Paul Churchland offers a novel account of how the brain constructs a representation -- or "takes a picture" -- of the universe's timeless categorical and dynamical structure. This construction process, which begins at birth, yields the enduring background conceptual framework with which we will interpret our sensory experience for the rest of our lives. But, as even Plato knew, to make singular perceptual judgments requires that we possess an antecedent framework of abstract categories (...) to which any perceived particular can be relevantly assimilated. How that background framework is assembled in the first place is the motivating mystery, and the primary target, of Churchland's book. Unexpectedly, this neurobiologically grounded account of human cognition also provides a systematic story of how such low-level epistemological activities are integrated within an enveloping framework of linguistic structures and regulatory mechanisms at the social level. As Churchland illustrates, this integration of cognitive mechanisms at several levels has launched the human race on an epistemological adventure denied to all other terrestrial creatures. (shrink)

Volume 1 of this biography of L. E. J. Brouwer was published in 1999.1 The volume under review here covers the period from the early nineteen twenties until Brouwer's death in 1966. It also includes a short epilogue that discusses the disposition of Brouwer's estate after his death, his influence on others, the paths of some of his students and colleagues, and other matters. Van Dalen notes in the Preface that in preparing this volume he consulted some historical studies that (...) appeared after the first volume was published. He also used new material from various archives. The biography contains interesting quotations from unpublished materials in the Brouwer Archive and from correspondence. The bibliographical references to Brouwer's publications, it should be noted, are somewhat different in this volume. This volume, like the first, contains some nice photographs and reproductions. I noted that there were many typographical errors in the earlier book but Volume 2 is relatively free of them.As is the case in Volume 1, the discussion of Brouwer's mathematical and philosophical work is woven into the narrative of Brouwer's life and times. The story in this volume starts with Brouwer's first contacts with Paul Alexandrov and Paul Urysohn in 1923. The interaction began when Urysohn announced that he had found a mistake in Brouwer's definition of dimension in Brouwer's 1913 paper on natural dimension. Was it just a slip of the pen, as Brouwer always maintained , or something more substantial? Urysohn and Alexandrov ultimately came to agree with Brouwer on the matter, and Urysohn was prepared to grant Brouwer priority for the definition of dimension. There were, however, ups and downs along the way. Karl Menger, through his own work in topology and dimension theory, soon got into the picture, and Brouwer and Menger were to …. (shrink)

Immanuel Kant claims that transcendental idealism yields a form of realism at the empirical level. Polite silence might best describe the reception this assertion has garnered among even sympathetic interpreters. This book challenges that prejudice, offering a controversial presentation and rehabilitation of Kant's empirical realism that places his realist credentials at the centre of the account of representation he offers in the Critique of Pure Reason. This interpretation ranges over the major themes contained in the Analytic of Principles and relevant (...) portions of the Dialectic. Kant's analysis of the conditions necessary for determinate representation is shown to involve a realist understanding of the relation of mind and world. The realist character of Kant's account of empirical truth, and his commitment to the unity of nature, are defended against competing empiricist, pragmatist, and methodological readings. This title links Kant studies to contemporary philosophical debates, and will appeal to scholars and students of Kant, as well as epistemologists, metaphysicians, and philosophers of science interested in a powerful, experience-sensitive, form of realism. (shrink)

When I began working on my dissertation on Kant’s aesthetic theory in 1971, I was able to read virtually all of the extant literature on the Critique of Judgment in English, German, andFrench going back to Hermann Cohen’s Kants Begr¨undung der A¨ sthetik of 1889, while also reading most of what I wanted to read of eighteenth-century British and German aesthetics before Kant—not because I had paid my dues to Evelyn Wood, but just because there was not all that much (...) to read.1 I pity the graduate student who sets out to write a dissertation on the third Critique now: since Donald Crawford, Francis Coleman, Jens Kulenkampff, Eva Schaper, and I published books on Kant’s aesthetics between 1974 and 1979 there has been a continuing flood of articles (this journal receives more submissions on Kant’s aesthetics annually than on any other historical topic) and books, a flood that has only accelerated since 2000. Confining myself only to monographs and anthologies on Kant’s aesthetics or the third Critique as a whole (but not those devoted exclusively to teleology) in English, German, and French on my shelves, and no doubt missing some, at least in German and French, I find twenty-eight monographs and anthologies published in the period between 1980 and 1999 and another twenty-seven just since 2000. (Indeed, two more have arrived on my desk since this article was written.)3 Someone setting out to work on the third Critique now has at least as many books from the last decade alone to read as I had in 1971 from the eight preceding decades. The present review will make only a small dent in this pile: I will discuss just five monographs and one introduction to the third Critique, all published in English in 2006 and 2007. (shrink)

In this astonishingly rich volume, experts in ethics, epistemology, philosophy of mind, political theory, aesthetics, history, critical theory, and hermeneutics bring to light the best philosophical scholarship on what is arguably Nietzsche's most rewarding but most challenging text. Including essays that were commissioned specifically for the volume as well as essays revised and edited by their authors, this collection showcases definitive works that have shaped Nietzsche studies alongside new works of interest to students and experts alike. A lengthy introduction, annotated (...) bibliography, and index make this an extremely useful guide for the classroom and advanced research. (shrink)

It has been argued that organizational structures (the way tasks are defined, allocated, and coordinated) can influence moral agency in organizations. In particular, low values on different structural parameters (functional concentration, specialization, separation, and formalization) are said to foster an organizational context (allowing for relating to the goals and output of the organization, moral deliberation, and social connectedness) that is conducive to moral agency. In this paper, we investigate the relation between the organizational structure and moral agency in the case (...) of a.s.r. (a large Dutch insurance company). While our empirical results fit the thesis that low values on structural parameters positively relate to moral agency, they also refine our understanding of the influence of structural parameters. In particular, our data suggest that the influence of functional concentration not only depends on whether it is low, but also on the type of criterion used for identifying business units; they suggest that the specific organizational context may put a limit to lowering design parameters and points at several non-structural factors that have an influence on the relation between structure and moral agency. In all, the paper contributes to a more detailed understanding of the conditions conducive to moral agency in organizations. (shrink)